Cell surface targeting of heat shock protein gp96 induces dendritic cell maturation and antitumor immunity.

Antitumor Immunity gp96 Induces Dendritic Cell Maturation and Cell Surface Targeting of Heat Shock Protein

Maturation and Antitumor Immunity Protein gp96 Induces Dendritic Cell Cell Surface Targeting of Heat Shock

Perforin Is Required for Innate and Adaptive Immunity Induced by Heat Shock Protein Gp96 of CD8 CTL in response to heat shock protein gp96- peptide comlexes, indicating an essential function for perforin-mediated lysis in the nascent NK and CD8 CTL

trauma, infection, or necrosis (Basu et al., 2000; Berwin Tumor-secreted gp96-Ig is highly immunogenic and et al., 2001). Gp96-peptide complexes bind to CD91 and triggers CD8 T cell-mediated tumor rejection. In vivo other receptors on dendritic cells (Basu et al., 2001; secreted gp96-Ig and gp96-myc cause NK activation Berwin et al., 2002; Binder et al., 2000), mediate endocyand clonal expansio...

Heat shock protein 70, released from heat-stressed tumor cells, initiates antitumor immunity by inducing tumor cell chemokine production and activating dendritic cells via TLR4 pathway.

Extracellular heat shock proteins (HSP) can activate dendritic cells (DC) and monocytes/macrophages, and HSP derived from tumor cells have been regarded as potent adjuvant facilitating presentation of tumor Ags and induction of antitumor immunity. However, the roles and the underlying mechanisms of releasable HSP in the induction of antitumor immunity have not been fully elucidated. In this stu...

Identification of gp96 as a Novel Target for Treatment of Autoimmune Disease in Mice

Heat shock proteins have been implicated as endogenous activators for dendritic cells (DCs). Chronic expression of heat shock protein gp96 on cell surfaces induces significant DC activations and systemic lupus erythematosus (SLE)-like phenotypes in mice. However, its potential as a therapeutic target against SLE remains to be evaluated. In this work, we conducted chemical approach to determine ...